What is Midol? Midol is an over-the-counter NSAID that relieves pain and inflammation from menstrual cramps, headaches, and other minor discomforts. Midol is a popular NSAID that reduces pain and edema. This over-the-counter pain medicine is popular for menstrual cramps, but it can also treat other problems. Midol can help you manage headaches, backaches, and ...